scholarly journals A multi-patch use of the habitat: testing the First-Passage Time analysis on roe deer Capreolus capreolus paths

2008 ◽  
Vol 14 (3) ◽  
pp. 339-349 ◽  
Author(s):  
Mael Le Corre ◽  
Maryline Pellerin ◽  
David Pinaud ◽  
Guy Van Laere ◽  
Hervé Fritz ◽  
...  
Keyword(s):  
Roe Deer ◽  
First Passage Time ◽  
Capreolus Capreolus ◽  
Passage Time ◽  
Time Analysis ◽  
First Passage ◽  
Patch Use

Evaluating wild Turkey movement ecology: An example using first-passage time analysis

2014 ◽  
Vol 38 (2) ◽  
pp. 407-413 ◽  
Author(s):  
Michael E. Byrne ◽  
Joshua D. Guthrie ◽  
Jason Hardin ◽  
Bret A. Collier ◽  
Michael J. Chamberlain
Keyword(s):  
First Passage Time ◽  
Movement Ecology ◽  
Passage Time ◽  
Wild Turkey ◽  
Time Analysis ◽  
First Passage

Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS

2021 ◽  
Vol 118 (45) ◽  
pp. e2103598118
Author(s):  
William Y. C. Huang ◽  
Steven Alvarez ◽  
Yasushi Kondo ◽  
John Kuriyan ◽  
Jay T. Groves
Keyword(s):  
Single Molecule ◽  
Cellular Signaling ◽  
First Passage Time ◽  
Passage Time ◽  
Nucleotide Exchange ◽  
Time Analysis ◽  
First Passage ◽  
Nucleotide Exchange Factor ◽  
Ras Activation ◽  
Son Of Sevenless

Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor (GEF) that plays a central role in numerous cellular signaling pathways. Like many other signaling molecules, SOS is autoinhibited in the cytosol and activates only after recruitment to the membrane. The mean activation time of individual SOS molecules has recently been measured to be ∼60 s, which is unexpectedly long and seemingly contradictory with cellular signaling timescales, which have been measured to be as fast as several seconds. Here, we rectify this discrepancy using a first-passage time analysis to reconstruct the effective signaling timescale of multiple SOS molecules from their single-molecule activation kinetics. Along with corresponding experimental measurements, this analysis reveals how the functional response time, comprised of many slowly activating molecules, can become substantially faster than the average molecular kinetics. This consequence stems from the enzymatic processivity of SOS in a highly out-of-equilibrium reaction cycle during receptor triggering. Ultimately, rare, early activation events dominate the macroscopic reaction dynamics.

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